Feb 19, 2019 busulfan is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Oct 01, 2019 do not put the busulfan injection into an intravenous bag or largevolume syringe that does not contain normal saline or d5w. Pharmacokinetics of oncedaily iv busulfan as part of. The bioavailability of oral busulfan shows large intraindividual variations ranging from 47% to 103% mean 80% in adults and from 22% to 120% mean 68% in children see section 5. See actual entry in rtecs for complete information. It is supplied as a clear, colorless, sterile, solution in 10 ml singledose vials. It uses a similar set of steps to inserting as an image, but does something different as a result. Busulfan is a bifunctional alkylating agent known chemically as 1,4butanediol, dimethanesulfonate. It is used prior to a stem cell transplant in patients with chronic myelogenous leukemia. This emedtv resource lists other precautions and warnings with busulfan, including a list of possible complications that may occur with the drug.
It is the drug of preference in treatment of chronic myelogenous or granulocytic leukemia because its. Busulfan 2 mg tablets summary of product characteristics smpc by aspen. Always add the busulfan injection to the diluent, not the diluent to the busulfan injection. Busulfan exhibits sn2alkylating kinetics which means the alkylating reaction is dependent upon the concentrations of both busulfan and the target compound. Busulfan investigated as a drug, mutagen, reproductive effector, and tumorigen. Busulfex busulfan injection is a potent cytotoxic drug that causes profound myelosuppression at the recommended dosage. Prior to taking busulfan, let your doctor know if you have a seizure disorder, lung disease, or allergies. Myleran busulfan chemotherapy, side effects navigating.
Busulfex busulfan injection is intended for intravenous administration. Furthermore, it is our endeavour to identify a simpli. Administer busulfex in combination with cyclophosphamide as a conditioning regimen. Do not put the busulfan injection into an intravenous bag or largevolume syringe that does not contain normal saline or d5w. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. In some diseases low drug exposures predisposed to failed. In the lancet haematology, imke bartelink and colleagues. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia although it has been largely replaced by newer drugs. Discuss the use of reliable forms of birth control with your doctor.
Find patient medical information for busulfan oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Busulfan was approved by the us food and drug administration fda for treatment of chronic myeloid leukemia cml in 1999. Busulfan binds to dna at the n7 position of guanine. Myleran busulfan chemotherapy, side effects navigating care. Busulfan exposure also comes with a high variability, especially in very. Seizures have been reported in patients receiving highdose oral busulfan at doses producing plasma drug levels similar to those achieved following the recommended dosage of busulfex.
Busulfan is a methanesulfonate ester that is butane1,4diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. Busulfex busulfan dose, indications, adverse effects. Busulfex is an intravenous form of busulfan, a chemotherapeutic agent commonly used as part of a conditioning regimen prior to haematopoietic stem cell transplantation. There is a black box warning for this drug as shown here. Highlights of prescribing information these highlights do not include all the information needed to use.
Busulfan is an alkylating agent originally given qid by mouth, generally with cyclophosphamide in the socalled bucy regimens. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Health hazards busulfan myleran is a bifunctional alkylating agent that appears to be cytotoxic to slowly proliferating or nonproliferating stem cell compartments. Physicochemical stability of busulfan in injectable. Busulfan injection fda prescribing information, side. Prescribing information myleran busulfan 2mg scored tablets warning myleran is a potent drug. Busulfan reacts more readily with thiol groups of amino acids and proteins than nitrogen mustards. Busulfan definition and meaning collins english dictionary. This prescription chemotherapy drug comes as a tablet that is taken once a day, until blood cell counts return to normal. The bifunctional alkylating agent busulfan bu has been used for. Common adverse reactions include rash, abdominal pain, constipation, diarrhea, nausea, stomatitis, vomiting, asthenia, dizziness, and headache adult indications and dosage. Only select registry of toxic effects of chemical substances rtecs data is presented here. From here, you can crop your screenshot, resize it, and position it.
Busulfan injection is used in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for treatment of chronic myelogenous leukemia busulfan belongs to the group of medicines known as alkylating agents. Busulfan is in a class of medications called alkylating agents. Busulfan as a myelosuppressive agent for generating stable. Busulfex is supplied as a sterile solution in 10 ml singleuse clear glass vials each containing 60 mg of busulfan at a concentration of 6 mgml for intravenous use. Click on the thumbnail that shows your open pdf document to select it. In highdose chemotherapy, in which precise dose delivery is of utmost importance for treatment. Talk to your doctor about the risks of taking busulfan. Standard operating procedure for busulfan myleran in animals 1. See full prescribing information for busulfan injection. Oral chemotherapy protocols busulfan gwent healthcare nhs trust 27082008 version 1. Weekly fbc is recommended when coadministering if not avoidable.
Therapeutic drug monitoring of busulfan for the management o. This process will then insert a screenshot of your open pdf document window into the powerpoint presentation. Busulfan was the mainstay of the chemotherapeutic treatment of chronic myeloid leukemia cml until it was displaced by the new gold standard, imatinib, though it is still in use to a degree as a result of the drugs relative low cost. To insert a pdf file as an object into a powerpoint presentation, you make it available to those youre sharing the presentation with. In some cases, health care professionals may use the trade name bulsufex or other names myleran when referring to the generic drug name busulfan. Mass spectra and chromatograms of busulfan and internal standard obtained from the analysis of the lowest calibration solution 25.
Busulfan oral myleran side effects, medical uses, and. Medlineplus information on busulfan myleran and busulfan bulsulfex lay language summaries of important information about these drugs. Busulfan comes as a tablet to take by mouth once a day. Finally, the stem cells are infused back into the patient. These examples have been automatically selected and may contain sensitive content. All transfer procedures require strict adherence to aseptic techniques, preferably employing a vertical laminar flow safety hood while wearing gloves and protective clothing.
Busulfan injection is an alkylating agent that is fda approved for the treatment of chronic myelogenous leukemia. Busulfan is a bifunctional dna alkylating agent often used clinically as an alternative to irradiation 5,6. Avoid the use of azole antifungal during busulfan treatment due to risk of venoocclusive disease if possible. Mass spectra and chromatograms of busulfan and internal standard obtained from the analysis of the lowest calibration solution 25 ngml. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling. The busulfan concentrations were analyzed and the matrix effect was calcufig. It should not be used unless a diagnosis of chronic myelogenous leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy. It is unknown if this drug passes into breast milk. What should i tell my health care provider before i. What are the possible side effects of busulfan busulfan, busulfex, myleran. Since that time, new data have become available, these have been incorporated into the monograph, and taken into consideration in the present evaluation. Busulfan is an orally administered anticancer alkylating agent used in the. An equal amounts of busulfan and is were spiked into the prepared plasma samples and the stock solutions.
Nov 16, 2017 what are the possible side effects of busulfan busulfan, busulfex, myleran. Busulfan is not recommended for use during pregnancy. Busulfan definition of busulfan by the free dictionary. Busulfan article about busulfan by the free dictionary. It is usually given every 6 hours for 4 days for a total of 16 doses before bone marrow transplant. For many years only an oral bu dosage form was available. Insert a pdf file as an object into a powerpoint presentation. If you become pregnant or think you may be pregnant, tell your doctor immediately. Busulfan injection, for intravenous infusion use initial u.
Standard operating procedure for busulfan myleran in animals. It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients. Highlights of prescribing information these highlights do not. The patients treated with oral busulfan received it 4 times daily every 6 hours over 4 consecutive days for.
Busulfan was considered by previous iarc working groups in 1973 and 1987 iarc, 1974, 1987a. Information for the user busulfan 6 mgml concentrate for solution for infusion busulfan read all of this leaflet carefully before you start using this medicine because it contains important information for you. It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. These highlights do not include all the information needed to.
The dose should be increased only if the response is inadequate after three weeks. An alkylating agent, c6h14o6s2, that is used as an antineoplastic drug in the treatment of chronic myelogenous leukemia. It seems to act by interfering with the function of the bone marrow. Busulfan is also being studied in the treatment of other types of cancer. Notably, busulfan can be safely administered to mice by intraperitoneal ip injection and does not require the specialized facilities and equipment necessary to irradiate mice. Busulfan comes as a solution liquid to be given intravenously into a vein over 2 hours by a doctor or nurse in a medical facility. Highlights of prescribing information these highlights do. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have. Busulfan dosage people who receive busulfan will be given a dosage based on their weight, response to the medicine, other medications they are taking, and a number of other factors. Despite prophylactic therapy with phenytoin, one seizure 142 patients was reported during an autologous transplantation clinical trial of busulfex.
Nov 16, 2017 busulfan is dissolved in n,ndimethylacetamide dma, 3. These highlights do not include all the information needed to use busulfan injection safely and effectively. Busulfan is dissolved in n,ndimethylacetamide dma, 3. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to. To bring you great quality, smallpdf has partnered with solid documents that offers the best conversion out there. Patients coadministered azole antifungals or metronidazole with conventional dose busulfan should be monitored for signs of busulfan toxicity. If your pdf is in a presentation format, the conversion should be no problem.
Busulfan is a cancer medicine that interferes with the growth and spread of cancer cells in the body. To keep a pdf file as a support document for your presentation insert the entire pdf into the presentation as an object that you can open and view during your presentation. Busulfan bu is an alkylating agent used as part of the. Population pharmacokinetics of busulfan in children. Busulfex fda prescribing information, side effects and uses. Busulfan dosing algorithm andsamplingstrategyinstem cell transplantation patients francine a. Insert pdf file content into a powerpoint presentation. Do not put the busulfex into an intravenous bag or largevolume syringe that does not contain normal. If you have any further questions, ask your doctor. A modifier provides the means by which the reporting physician or provider can indicate that a service or procedure that has been performed has been altered by some specific circumstance but not changed in its definition or code.
Busulfan definition, a potent cytotoxic substance, c6h14o6s2, used in the treatment of chronic myeloid leukemia. Find patient medical information for busulfan intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Unfortunately, inserting pdf content is not possible when editing a presentation in powerpoint for the web. Infusion pumps should be used to administer the diluted busulfan injection solution. Busulfex busulfan side effects, images, uses, dosage. As a result, buinduced myelotoxicity has been complemented by adding lymphotoxic agents. Quantification of human plasmabusulfan concentration by.
These highlights do not include all the information needed. Busulfan 2 mg tablets summary of product characteristics. How to crop pictures in word, excel, and powerpoint 2010. Busulfan is used treat a certain type of chronic myelogenous leukemia cml.96 353 1294 933 560 790 327 1230 1493 748 202 461 339 511 78 1085 282 819 239 1000 339 1007 1453 558 1100 754 1572 554 428 387 1209 887 1102 603 151 569 306 1499 1412 527